If you're noticing input and output audio issues related to VB Cable, you can try changing the settings in VB Cable this way:
Go to the Control panel
Open the Sound settings
Choose the Record tab
Click the VB Cable (Output) Properties button.
Opened Advanced tab.
Uncheck the checked boxes (Exclusive use of the input)
Both the input and output audio on both Skype and Spreaker Studio should then work properly.